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Elucidating the role of 8q24 in colorectal cancer

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An Erratum to this article was published on 01 October 2009

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Two new reports highlight the power of genome-wide association (GWA) studies to guide the functional annotation of genetic variants contributing to common diseases. The studies show that a common risk variant for colorectal cancer on chromosome 8q24 affects TCF4 binding to an enhancer that interacts with the MYC promoter, providing a mechanistic explanation for the association of this variant with disease risk.

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Figure 1: From association to function.

Change history

  • 27 August 2009

    NOTE: In the version of this article initially published, there were two errors in the author contact information. The authors are at Scripps Genomic Medicine, Scripps Translational Science Institute and the Scripps Research Institute, La Jolla, California, USA; e-mail: kfrazer@scripps.edu or kafrazer@ucsd.edu.These errors have been corrected in the HTML and PDF versions of the article.

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Authors and Affiliations

  1. Olivier Harismendy and Kelly A. Frazer are at Scripps Genomic Medicine, Scripps Translational Science Institute and the Scripps Research Institute, La Jolla, California, USA. kfrazer@scripps.edu or kafrazer@ucsd.edu,

    Olivier Harismendy & Kelly A. Frazer

Authors
  1. Olivier Harismendy
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  2. Kelly A. Frazer
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Harismendy, O., Frazer, K. Elucidating the role of 8q24 in colorectal cancer. Nat Genet 41, 868–869 (2009). https://doi.org/10.1038/ng0809-868

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