Developmentally regulated expression of the transcriptional repressor Prdm1 (Blimp1) in the early mammalian embryo controls global epigenetic changes required for specification of primordial germ cells. A new study demonstrates that a close family member, Prdm14, similarly activated in response to Bmp and Smad signals, also has an essential role during establishment of the germ cell lineage.
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Bikoff, E., Robertson, E. One PRDM is not enough for germ cell development. Nat Genet 40, 934–935 (2008). https://doi.org/10.1038/ng0808-934
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DOI: https://doi.org/10.1038/ng0808-934
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