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Axons need glial peroxisomes

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Several devastating genetic diseases illustrate that peroxisomes are essential to the development and functioning of the central nervous system. New work using a mouse model now shows that peroxisome integrity in oligodendrocytes is essential for axonal maintenance.

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Figure 1: Oligodendrocyte peroxisomes.

References

  1. Wanders, R.J.A. & Waterham, H. Annu. Rev. Biochem. 75, 295–332 (2006).

    Article  CAS  Google Scholar 

  2. Kassmann, C.M. et al. Nat Genet. 39, 969–976 (2007).

    Article  CAS  Google Scholar 

  3. Lappe-Siefke, C. et al. Nat. Genet. 33, 366–374 (2003).

    Article  CAS  Google Scholar 

  4. Dubois-Dalcq, M., Feigenbaum, V. & Aubourg, P. Trends Neurosci. 22, 4–12 (1999).

    Article  CAS  Google Scholar 

  5. Pujol, A. et al. Hum. Mol. Genet. 11, 499–505 (2002).

    Article  CAS  Google Scholar 

  6. Pujol, A. et al. J. Neurochem. 101 (Suppl.), 66 (2007).

    Google Scholar 

  7. Goldfischer, S. et al. Science 182, 62–64 (1973).

    Article  CAS  Google Scholar 

  8. Ito, M. et al. J. Neuropathol. Exp. Neurol. 60, 1004–1019 (2001).

    Article  CAS  Google Scholar 

  9. Johnson, A.J. et al. Int. Rev. Neurobiol. 79, 73–97 (2007).

    Article  CAS  Google Scholar 

  10. Brisebois, M. et al. J. Immunol. 177, 2403–2411 (2006).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatric Neurology, Patrick Aubourg is at INSERM U745, Hôpital Saint-Vincent de Paul, University René Descartes, Paris 75014, France. aubourg@paris5.inserm.fr,

    Patrick Aubourg

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  1. Patrick Aubourg
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Aubourg, P. Axons need glial peroxisomes. Nat Genet 39, 936–938 (2007). https://doi.org/10.1038/ng0807-936

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