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From worm genetic networks to complex human diseases

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Systematic mapping of genetic interactions for Caenorhabditis elegans genes involved in signaling pathways implicated in human disease reveals a network of 350 interactions. The topology of this network resembles that mapped previously in yeast, reinforcing the idea that similar networks may underlie the genetic basis of complex human disease.

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Authors and Affiliations

  1. Biology Department, McGill University, Montreal, Quebec, Canada

    Howard Bussey

  2. Banting and Best Department of Medical Research and Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Canada

    Brenda Andrews & Charles Boone

Authors
  1. Howard Bussey
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  2. Brenda Andrews
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  3. Charles Boone
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Bussey, H., Andrews, B. & Boone, C. From worm genetic networks to complex human diseases. Nat Genet 38, 862–863 (2006). https://doi.org/10.1038/ng0806-862

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  • DOI: https://doi.org/10.1038/ng0806-862

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