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Splicing on the brain

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A new study describes the use of an alternative splicing microarray to identify exons regulated by the neural-specific Nova splicing factors. Nova2 is also shown to coordinately regulate splicing of a group of functionally related genes that encode a network of interacting proteins at the synapse.

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Figure 1: Profiling alternative splicing in neocortex from wild-type and mutant mice lacking Nova2 identifies a set of coregulated alternative exons in genes associated predominantly with synapse activity.

Katie Ris

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Authors and Affiliations

  1. Banting and Best Department of Medical Research, University of Toronto, Ontario, M5G 1L6, Canada

    Benjamin J Blencowe

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  1. Benjamin J Blencowe
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Blencowe, B. Splicing on the brain. Nat Genet 37, 796–797 (2005). https://doi.org/10.1038/ng0805-796

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  • DOI: https://doi.org/10.1038/ng0805-796

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