The molecular pathogenesis of most forms of amyotrophic lateral sclerosis (ALS) is poorly understood. Now, reduced expression of vascular endothelial growth factor (VEGF) is shown to be a risk factor for contracting ALS. Addition of Vegf in mice is shown to protect motoneurons from damage.
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References
Brown, R.H. Jr. & Robberecht, W. Semin. Neurol. 21, 131–139 (2001).
Cleveland, D.W. & Rothstein, J.D. Nat. Rev. Neurosci. 2, 806–819 (2001).
Hadano, S. et al. Nat Genet. 29, 103–104 (2001).
Lambrechts, D. et al. Nat. Genet. 34, 383–394 (2003).
Carmeliet, P. et al. Nature 380, 435–439 (1996).
Ferrara, N. et al. Nature 380, 439–442 (1996).
Kaelin, W.G. Jr. Genes Dev. 16, 1441–1445 (2002).
Oosthuye, B. et al. Nat. Genet. 28, 131–138 (2001).
Brogan, I.J. et al. Human Immunol. 60, 1245–1249 (1999).
Huez, I. et al. Mol. Endocrinol. 15, 2197–2210 (2001).
Tu, P.H. et al. Proc. Natl. Acad. Sci. USA 93, 3155–3160 (1996).
Ogunshola, O.O. et al. J. Biol. Chem. 277, 11410–11415 (2002).
Jin, K.L., Mao, X.O. & Greenberg, D.A. Proc. Natl. Acad. Sci USA 97, 10242–10247 (2000).
Ivan, M. et al. Proc. Natl. Acad. Sci. USA 99, 13459–13464 (2002).
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Cleveland, J. A new piece of the ALS puzzle. Nat Genet 34, 357–358 (2003). https://doi.org/10.1038/ng0803-357
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DOI: https://doi.org/10.1038/ng0803-357
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