Nephronophthisis is the most common inherited cause of renal failure in children. Two new studies add to the growing body of literature that suggests that cilial dysfunction may underlie all forms of cystic renal disease.
This is a preview of subscription content, log in via an institution to check access.
References
Otto, E.A. et al. Nat. Genet. 34, 413–420 (2003).
Olbrich, H. et al. Nat. Genet. 34, 455–459 (2003).
Hildebrandt, F. et al. Nat. Genet. 17, 149–153 (1997).
Mollet, G. et al. Nat. Genet. 32, 300–305 (2002).
Donaldson, J.C. et al. J. Biol. Chem. 277, 29028–29035 (2002).
Benzing, T. et al. Proc. Natl. Acad. Sci. USA 98, 9784–9789 (2001).
Mochizuki, T. et al. Nature 395, 177–181 (1998).
Morgan, D. et al. Hum. Mol. Genet. 11, 3345–3350 (2002).
Ostrowski, L.E. et al. Mol. Cell. Proteomics 1, 451–465 (2002).
Calvet, J.P. et al. Nat. Genet. 33, 113–114 (2003).
Praetorius, H. & Spring, K.R. J. Membr. Biol. 184, 71–79 (2001).
Nauli, S.M. et al. Nat. Genet. 33, 129–137 (2003).
Boletta, A. & Germino, G.G. Trends Cell Biol. (in the press).
Nurnberger, J. et al. Mol. Biol. Cell 13, 3096–3106 (2002).
Brown, N.E., Murcia, N.S. Kidney Int. 63, 1220–1229 (2003).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Watnick, T., Germino, G. From cilia to cyst. Nat Genet 34, 355–356 (2003). https://doi.org/10.1038/ng0803-355
Issue Date:
DOI: https://doi.org/10.1038/ng0803-355
- Springer Nature America, Inc.
This article is cited by
-
The pathobiology of polycystic kidney disease from a metabolic viewpoint
Nature Reviews Nephrology (2019)
-
Genetic kidney diseases: Caenorhabditis elegans as model system
Cell and Tissue Research (2017)
-
Hepatorenal fibrocystic diseases in children
Pediatric Nephrology (2016)