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Hints of hidden heritability in GWAS

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Although susceptibility loci identified through genome-wide association studies (GWAS) typically explain only a small proportion of the heritability, a classical quantitative genetic analysis now argues that considering together all common SNPs can explain a large proportion of the heritability of these complex traits. A related study provides recommendations for the sample sizes needed in future GWAS to identify additional susceptibility loci.

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Figure 1: Predictive power of genetic variants identified through genome-wide association studies.

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  1. Greg Gibson is in the School of Biology, Georgia Institute of Technology, Atlanta, Georgia, USA.,

    Greg Gibson

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  1. Greg Gibson
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Correspondence to Greg Gibson.

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The author declares no competing financial interests.

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Gibson, G. Hints of hidden heritability in GWAS. Nat Genet 42, 558–560 (2010). https://doi.org/10.1038/ng0710-558

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