Genome-wide association studies, exemplified by the Wellcome Trust Case Control Consortium and follow-up studies, have identified dozens of common variants robustly associated with common diseases, providing new clues about genetic architecture in humans. Finding all such loci, and fully defining genotype-phenotype correlation, will be a key to translating initial clues into pathophysiological understanding and clinical prediction.
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Altshuler, D., Daly, M. Guilt beyond a reasonable doubt. Nat Genet 39, 813–815 (2007). https://doi.org/10.1038/ng0707-813
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DOI: https://doi.org/10.1038/ng0707-813
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