Muscle mitochondrial respiratory metabolism is reduced in aging and diabetes. Now, coordinated changes in expression of genes involved in oxidative phosphorylation have been found in individuals with type 2 diabetes mellitus (DM2). Peroxisome proliferator activator protein-γ co-activator-1α (PGC-1α) seems to be in charge of this orchestrated change in gene expression.
References
Holloszy, J.O. J. Biol. Chem. 242, 2278–2282 (1967).
Hood, D.A. J. Appl. Physiol. 90, 1137–1157 (2001).
Regensteiner, J.G. et al. J. Appl. Physiol. 85, 310–317 (1998).
Kelley, D.E., He, J., Menshikova, E.V. & Ritov, V.B. Diabetes 51, 2944–2950 (2002).
Puigserver, P. & Spiegelman, B.M. Endocr. Rev. 24, 78–90 (2003).
Mootha, V.K. et al. Nat. Genet. 34, 267–273 (2003).
Hardie, D.G., Carling, D. & Carlson, M. Annu. Rev. Biochem. 67, 821–855 (1998).
Sakamoto, K. & Goodyear, L.J. J. Appl. Physiol. 93, 369–383 (2002).
Handschin, C., Rhee, J., Lin, J., Tarr, P.T. & Spiegelman, B.M. Proc. Natl. Acad. Sci. USA (in the press).
Wu, H. et al. Science 296, 349–352 (2002).
Obici, S. et al. J. Clin. Invest. 109, 1599–1605 (2002).
Koubova, J. & Guarente, L. Genes Dev. 17, 313–321 (2003).
Neel, J.V. Am. J. Hum. Genet. 14, 353–362 (1962).
Patti, M.E. et al. Proc. Natl. Acad. Sci. USA (in the press).
Petersen, K.F. et al. Science 300, 1140–1142 (2003).
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Attie, A., Kendziorski, C. PGC-1α at the crossroads of type 2 diabetes. Nat Genet 34, 244–245 (2003). https://doi.org/10.1038/ng0703-244
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DOI: https://doi.org/10.1038/ng0703-244
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