Skip to main content
SpringerLink
Log in

Cancer, cadmium and genome integrity

  • News & Views
  • Published:

From Nature Genetics

View current issue Submit your manuscript

The direct inhibition of DNA mismatch repair by cadmium provides a molecular mechanism for cadmium toxicity with profound implications for human health, risk assessment and biological understanding of environmental mutagens. Alteration of key DNA damage response pathways may prove even more important than direct DNA damage by mutagens.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: A beautiful toxin.

Corel royalty-free art photo image 523028

Figure 2: Cadmium poisoning of MMR enzymes and resulting mutations.

Katie Ris

References

  1. Jin, Y.H. et al. Nat. Genet. 34, 326–329 (2003).

    Article  CAS  Google Scholar 

  2. Hayes, R.B. Cancer Causes Control, 8 371–385 (1997).

    Article  CAS  Google Scholar 

  3. Hengstler, J.G. et al. Carcinogenesis 24, 63–73 (2003).

    Article  CAS  Google Scholar 

  4. Friedberg, E.C. Nature 421, 436–440 (2003).

    Article  Google Scholar 

  5. Hoeijmakers, J.H. Nature 411, 366–374 (2001).

    Article  CAS  Google Scholar 

  6. Kolodner, R.D., Putnam. C.D. & Myung, K. Science 297, 552–557 (2002).

    Article  CAS  Google Scholar 

  7. Drotschmann, K. et al. J. Biol. Chem. 383, 969–975 (2002).

    CAS  Google Scholar 

  8. McMurray, C.T. Lancet 358, S37 (2001).

    Article  Google Scholar 

  9. Kovtun, I.V. & McMurray, C.T. Nat. Genet. 27, 407–411 (2001).

    Article  CAS  Google Scholar 

  10. Thilly, W.G. Nat. Genet. 34, 255–259 (2003).

    Article  CAS  Google Scholar 

  11. Castagnetto, J.M. et al. Nucleic Acids Res. 30, 379–382 (2002).

    Article  CAS  Google Scholar 

  12. Hopfner, K.P. et al. Nature 418, 562–566 (2002).

    Article  CAS  Google Scholar 

  13. Laity, J.H., Lee, B.M. & Wright, P.E. Curr. Opin. Struct. Biol. 11, 39–46 (2001).

    Article  CAS  Google Scholar 

  14. Hopfner, K.-P. & Tainer, J.A. Curr. Opin. Struct. Biol. 13, 249–255 (2003).

    Article  CAS  Google Scholar 

  15. McMurray, C.T. Trends Neurol. Sci. 24, S32–S38 (2001).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic and Foundation, Rochester, 55905, Minnesota, USA

    Cynthia T McMurray

  2. Department of Molecular Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, 92037, California, USA

    John A Tainer

  3. Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, 94720, California, USA

    John A Tainer

Authors
  1. Cynthia T McMurray
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. John A Tainer
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

McMurray, C., Tainer, J. Cancer, cadmium and genome integrity. Nat Genet 34, 239–241 (2003). https://doi.org/10.1038/ng0703-239

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng0703-239

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation