Although common obesity has a strong genetic component, there has been little success in the discovery of the underlying genetic causes. This has now changed, as two independent studies demonstrate strong association between variants in a gene called FTO and obesity.
References
Farooqi, S. & O'Rahilly, S. Endocr. Rev. 27, 710–718 (2006).
Boutin, P. et al. PLoS Biol. 1, E68 (2003).
Meyre, D. et al. Nat. Genet. 37, 863–867 (2005).
Herbert, A. et al. Science 312, 279–283 (2006).
Dina, C. et al. Nat. Genet. 39, 724–726 (2007).
Frayling, T. et al. Science, published online 12 April 2007 (doi:10.1126/science.1141634).
Sladek, R. et al. Nature 445, 881–885 (2007).
Diabetes Genetic Initiative et al. Science, published online 26 April 2007 (doi:10.1126/science.1142358).
Scott, L.J. et al. Science, published online 26 April 2007 (doi:10.1126/science.1142382).
van der Hoeven, F. et al. Development 120, 2601–2607 (1994).
Peters, T. et al. Mamm. Genome 10, 983–986 (1999).
Peters, T. et al. Mamm. Genome 13, 186–188 (2002).
Fan, Y. et al. Nat. Genet. 36, 989–993 (2004).
Benzinou, M. et al. Diabetes 55, 2876–2882 (2006).
Stratakis, C.A. et al. J. Clin. Endocrinol. Metab. 85, 3396–3401 (2000).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Groop, L. From fused toes in mice to human obesity. Nat Genet 39, 706–707 (2007). https://doi.org/10.1038/ng0607-706
Issue Date:
DOI: https://doi.org/10.1038/ng0607-706
- Springer Nature America, Inc.
This article is cited by
-
Association between a frequent variant of the FTO gene and anthropometric phenotypes in Brazilian children
BMC Medical Genetics (2013)
-
Shared ancestral susceptibility to colorectal cancer and other nutrition related diseases
BMC Medical Genetics (2012)
-
A loop matters for FTO substrate selection
Protein & Cell (2010)
-
Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample
Cardiovascular Diabetology (2008)
-
The FTO Gene, Implicated in Human Obesity, Is Found Only in Vertebrates and Marine Algae
Journal of Molecular Evolution (2008)