Two new studies evaluate the extent to which widely used SNP platforms capture common variation in different populations, and they present strategies for improving power in whole-genome association studies using fixed marker sets. Their results suggest that genome-wide association studies are finally ready to move from theory to practice.
This is a preview of subscription content, log in via an institution to check access.
References
Cohen, D., Chumakov, I. & Weissenbach, J. Nature 366, 698–701 (1993).
Lander, E.S. et al. Nature 409, 860–921 (2001).
Venter, J.C. et al. Science 291, 1304–1351 (2001).
Sachidanandam, R. et al. Nature 409, 928–933 (2001).
Hinds, D.A. et al. Science 307, 1072–1079 (2005).
Altshuler, D. et al. Nature 437, 1299–1320 (2005).
Risch, N. & Merikangas, K. Science 273, 1516–1517 (1996).
Carlson, C.S. et al. Am. J. Hum. Genet. 74, 106–120 (2004).
de Bakker, P.I. et al. Nat. Genet. 37, 1217–1223 (2005).
Ke, X. & Cardon, L.R. Bioinformatics 19, 287–288 (2003).
Barrett, J.C. & Cardon, L.R. Nat. Genet. 38, 659–662 (2006).
Pe'er, I. et al. Nat. Genet. 38, 663–667 (2006).
Matsuzaki, H. et al. Nat. Methods 1, 109–111 (2004).
Steemers, F.J. et al. Nat. Methods 3, 31–33 (2006).
Gunderson, K.L., Steemers, F.J., Lee, G., Mendoza, L.G. & Chee, M.S. Nat. Genet. 37, 549–554 (2005).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Carlson, C. Agnosticism and equity in genome-wide association studies. Nat Genet 38, 605–606 (2006). https://doi.org/10.1038/ng0606-605
Issue Date:
DOI: https://doi.org/10.1038/ng0606-605
- Springer Nature America, Inc.
This article is cited by
-
Singleton SNPs in the human genome and implications for genome-wide association studies
European Journal of Human Genetics (2008)