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Epigenetic interplay

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In a new study, the presence of a CpG island transgene protects neighboring sequence from DNA methylation during development leading to an open chromatin state that persists in the adult animal. This study suggests the importance of DNA methylation in setting up the epigenome.

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Figure 1: The epigenetic balance.

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Authors and Affiliations

  1. Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, 20892, Maryland, USA

    Kye-Yoon Park & Karl Pfeifer

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  1. Kye-Yoon Park
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  2. Karl Pfeifer
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Correspondence to Karl Pfeifer.

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Park, KY., Pfeifer, K. Epigenetic interplay. Nat Genet 34, 126–128 (2003). https://doi.org/10.1038/ng0603-126

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