The human genome contains up to four paralogs of many Drosophila genes. Two rounds of whole-genome duplication followed by substantial gene loss could explain this pattern easily, but this hypothesis has often been questioned. Mounting evidence from the human genome sequence now confirms at least one genome duplication during early chordate evolution.
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Spring, J. Genome duplication strikes back. Nat Genet 31, 128–129 (2002). https://doi.org/10.1038/ng0602-128
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DOI: https://doi.org/10.1038/ng0602-128
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