Cytokines regulate growth and functions of a variety of cells including immune and hematopoietic cells. The SOCS family proteins negatively regulate cytokine signaling, thereby preventing overactivation of cytokine-stimulated cells. A new study provides evidence that inactivation of SOCS-1, one of the SOCS family members, can be responsible for abnormal growth of hepatocellular carcinoma cells, suggesting that SOCS-1 may act as a tumor suppressor.
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References
Kishimoto, T., Taga, T. & Akira, S. Cell 76, 253–262 (1994).
Nicola, N.A. et al. Cold Spring Harb. Symp. Quant. Biol. 64, 397–404 (1999).
Yoshikawa, H. et al. Nature Genet. 28, 29–35 (2001).
Starr, R. et al. Nature 387, 917–921 (1997).
Endo, T.A. et al. Nature 387, 921–924 (1997).
Naka, T. et al. Nature 387, 924–929 (1997).
Alexander, W.S. Cell 98, 597–608 (1999).
Naka, T. et al. Proc. Natl. Acad. Sci. USA 95, 15577–15582 (1998).
Suematsu, S. et al. Proc. Natl. Acad. Sci. USA 89, 232–235 (1989).
Yu, C.L. et al. Science 269, 81–83 (1995).
Migone, T.S. Science 269, 79–81 (1995).
Bromberg, J.F. et al. Cell 98, 295–303 (1999).
Catlett-Falcone, R. et al. Immunity 10, 105–115 (1999).
Luo, H., Hanratty, W.P. & Dearolf, C.R. EMBO J. 14, 1412–1420 (1995).
Lacronique, V. et al. Science 278, 1309–1312 (1997).
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Kishimoto, T., Kikutani, H. Knocking the SOCS off a tumor suppressor. Nat Genet 28, 4–5 (2001). https://doi.org/10.1038/ng0501-4
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DOI: https://doi.org/10.1038/ng0501-4
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