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Adding pathogens by genomic subtraction

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Two studies report the application of high-throughput sequencing technologies to discover infectious agents associated with diseased human tissues. These findings herald a breakthrough in the field of pathogen discovery.

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Figure 1: Computational subtraction involves interrogation of diseased human tissue by sequencing.

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Authors and Affiliations

  1. Laura MacConaill & Matthew Meyerson are in the Center for Cancer Genome Discovery and Department of Medical Oncology at the Dana-Farber Cancer Institute and the Department of Pathology at Harvard Medical School, Boston, Massachusetts 02115, USA and the Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. matthew_meyerson@dfci.harvard.edu,

    Laura MacConaill & Matthew Meyerson

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  1. Laura MacConaill
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  2. Matthew Meyerson
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MacConaill, L., Meyerson, M. Adding pathogens by genomic subtraction. Nat Genet 40, 380–382 (2008). https://doi.org/10.1038/ng0408-380

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