Studies of rare genetic disorders in humans have yielded important insights into the function of the hypothalamic-pituitary-gonadal axis. A new study now establishes a fundamental role for the neurokinin B pathway in normal reproductive function.
References
Trarbach, E.B. et al. Pituitary 10, 381–391 (2007).
Grumbach, M.M. Horm. Res. 57, 2–14 (2002).
Seminara, S.B. & Crowley, W.F., Jr. J. Neuroendocrinol. 20, 727–731 (2008).
Dodé, C. & Hardelin, J.P. Eur. J. Hum. Genet. 17, 139–146 (2009).
Hardelin, J.P. & Dodé, C . Sex. Dev. 2, 181–193 (2008).
Pitteloud, N. et al. Proc. Natl. Acad. Sci. USA 103, 6281–6286 (2006).
Pitteloud, N. et al. Proc. Natl. Acad. Sci. USA 104, 17447–17452 (2007).
Topaloglu, A.K. et al. Nat. Genet. 41, 354–358 (2009).
Almeida, T.A. et al. Curr. Med. Chem. 11, 2045–2081 (2004).
Klassert, T.E. et al. J. Neuroimmunol. 196, 27–34 (2008).
Krajewski, S.J. et al. J. Comp. Neurol. 489, 372–386 (2005).
Rance, N.E. Peptides 30, 111–122 (2009).
Pitteloud, N. et al. J. Clin. Invest. 117, 457–463 (2007).
Teles, M.G. et al. N. Engl. J. Med. 358, 709–715 (2008).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Latronico, A. The neurokinin B pathway in human reproduction. Nat Genet 41, 269–270 (2009). https://doi.org/10.1038/ng0309-269
Issue Date:
DOI: https://doi.org/10.1038/ng0309-269
- Springer Nature America, Inc.