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Mapping expression in randomized rodent genomes

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Gene expression microarray data on each individual in a pedigree or from an experimental cross enable the identification of the genetic determinants of variation in gene expression. Three new studies apply this approach to rodent recombinant inbred lines and provide new insights into the nature of variation in gene expression and its connection to disease.

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Figure 1: The production of RI lines by sibling mating: crossing of two inbred strains is followed by repeated sibling mating to produce a new inbred line whose genome is a mosaic of the two parental genomes.

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  1. the Department of Biostatistics, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, 21205, Maryland, USA

    Karl W Broman

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  1. Karl W Broman
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Broman, K. Mapping expression in randomized rodent genomes. Nat Genet 37, 209–210 (2005). https://doi.org/10.1038/ng0305-209

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