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Fanconi anemia and breast cancer susceptibility

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Two new studies show that the Fanconi anemia complementation group N results from biallelic mutations in PALB2, which encodes a recently identified interaction partner of the breast cancer susceptibility protein BRCA2. A third study shows that monoallelic PALB2 mutations are associated with breast cancer susceptibility, providing yet more links between Fanconi anemia, homologous recombination repair and cancer predisposition.

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Figure 1: Overview of known Fanconi anemia gene products, their interactions and their putative role in DNA repair.

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  1. Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, UK

    Ketan J Patel

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  1. Ketan J Patel
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Patel, K. Fanconi anemia and breast cancer susceptibility. Nat Genet 39, 142–143 (2007). https://doi.org/10.1038/ng0207-142

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