To understand transcriptional regulation, it is necessary to understand the factors that determine where a particular transcription factor binds in the genome. A new study demonstrates that a single protein, FoxA1, can dictate the global DNA binding profile and the transcriptional function of estrogen receptor a in breast cancer cells and in other cell types.
This is a preview of subscription content, log in via an institution to check access.
References
Carroll, J.S. et al. Nat. Genet. 38, 1289–1297 (2006).
Lin, C.Y. et al. PLoS Genet. 3, e87 (2007).
Fullwood, M.J. et al. Nature 462, 58–64 (2009).
Lupien, M. et al. Cell 132, 958–970 (2008).
Carroll, J.S. et al. Cell 122, 27–33 (2005).
Hurtado, A. et al. Nat. Genet. 43, 27–33 (2011).
Green, K.A. & Carroll, J.S. Nat. Rev. Cancer 7, 713–722 (2007).
Cirillo, L.A. et al. EMBO J. 17, 244–254 (1998).
Cirillo, L.A. et al. Mol. Cell 9, 279–289 (2002).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Cheung, E., Ruan, Y. Determination of transcription factor binding. Nat Genet 43, 11–12 (2011). https://doi.org/10.1038/ng0111-11
Published:
Issue Date:
DOI: https://doi.org/10.1038/ng0111-11
- Springer Nature America, Inc.