Networks of investigators have begun sharing best practices, tools and methods for analysis of associations between genetic variation and common diseases. A Network of Investigator Networks has been set up to drive the process, sponsored by the Human Genome Epidemiology Network. A workshop is planned to develop consensus guidelines for reporting results of genetic association studies. Published literature databases will be integrated, and unpublished data, including 'negative' studies, will be captured by online journals and through investigator networks. Systematic reviews will be expanded to include more meta-analyses of individual-level data and prospective meta-analyses. Field synopses will offer regularly updated overviews.
References
Anonymous. Nat. Genet. 37, 1153 (2005).
Little, J. et al. Am. J. Epidemiol. 157, 667–673 (2003).
Ioannidis, J.P. et al. Am. J. Epidemiol. 162, 302–304 (2005).
von Elm, E. & Egger, M. Br. Med. J. 329, 868–869 (2004).
Altman, D.G. et al. Ann. Intern. Med. 134, 663–694 (2001).
Brazma, A. et al. Nat. Genet. 29, 365–371 (2001).
Thorn, C.F., Klein, T.E. & Altman, R.B. Methods Mol. Biol. 311, 179–191 (2005).
Pan, Z., Trikalinos, T.A., Kavvoura, F.K., Lau, J. & Ioannidis, J.P. PLoS Med. 2, e334 (2005).
Easterbrook, P.J., Berlin, J.A., Gopalan, R. & Matthews, D.R. Lancet 337, 867–872 (1991).
Greenland, S. J. R. Stat. Soc. [Ser. A] 168, 267–306 (2005).
Wacholder, S., Chanock, S., Garcia-Closas, M., El Ghormli, L. & Rothman, N. J. Natl. Cancer Inst. 96, 434–442 (2004).
Ioannidis, J.P. PLoS Med. 2, e124 (2005).
Chan, A.W., Hrobjartsson, A., Haahr, M.T., Gotzsche, P.C. & Altman, D.G. J. Am. Med. Assoc. 291, 2457–2465 (2004).
Patterson, M. & Cardon, L. PLoS Biol. 3, e327 (2005).
Patsopoulos, N.A., Analatos, A.A. & Ioannidis, J.P. J. Am. Med. Assoc. 293, 2362–2366 (2005).
Ioannidis, J.P., Rosenberg, P.S., Goedert, J.J. & O'Brien, T.R. Am. J. Epidemiol. 156, 204–210 (2002).
Rebbeck, T.R. et al. Cancer Epidemiol. Biomarkers Prev. 13, 1985–1986 (2004).
Ioannidis, J.P. Int. J. Epidemiol. (in the press).
Huizinga, T.W., Pisetsky, D.S. & Kimberly, R.P. Arthritis Rheum. 50, 2066–2071 (2004).
Freimer, N.B. & Sabatti, C. Hum. Mol. Genet. 14, 2481–2483 (2005).
Wacholder, S. Cancer Epidemiol. Biomarkers Prev. 14, 1361 (2005).
Weiss, S.T. Am. J. Respir. Crit. Care Med. 164, 2014–2015 (2001).
Cooper, D.N., Nussbaum, R.L. & Krawczak, M. Hum. Genet. 110, 207–208 (2002).
Marchini, J., Donnelly, P. & Cardon, L.R. Nat. Genet. 37, 413–417 (2005).
Author information
Authors and Affiliations
Consortia
Rights and permissions
About this article
Cite this article
Ioannidis, J., Gwinn, M., Little, J. et al. A road map for efficient and reliable human genome epidemiology. Nat Genet 38, 3–5 (2006). https://doi.org/10.1038/ng0106-3
Issue Date:
DOI: https://doi.org/10.1038/ng0106-3
- Springer Nature America, Inc.
This article is cited by
-
Genetics of rheumatic fever and rheumatic heart disease
Nature Reviews Cardiology (2020)
-
A systematic review of cancer GWAS and candidate gene meta-analyses reveals limited overlap but similar effect sizes
European Journal of Human Genetics (2014)
-
CER1gene variations associated with bone mineral density, bone markers, and early menopause in postmenopausal women
Human Genomics (2013)
-
Assessment of systematic effects of methodological characteristics on candidate genetic associations
Human Genetics (2013)
-
Response to 'Gene-by-environment experiments: a new approach to finding the missing heritability' by van IJzendoorn et al.
Nature Reviews Genetics (2011)