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Amyloid double trouble

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A new study shows that some cases of early-onset Alzheimer disease result from duplications of the APP locus, which encodes the amyloid β precursor protein. This finding fulfills a 20-year-old prediction that genetic variability in APP expression could lead to disease and provides further, perhaps definitive, evidence for the amyloid hypothesis of the disorder.

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Figure 1: Genetic factors influencing Aβ42 production and Alzheimer disease onset.

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  1. Laboratory of Neurogenetics, National Institute on Aging, Porter Neuroscience Building, 35 Convent Drive, Bethesda, 20892, Maryland, USA

    John Hardy

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  1. John Hardy
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Hardy, J. Amyloid double trouble. Nat Genet 38, 11–12 (2006). https://doi.org/10.1038/ng0106-11

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