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Regulating mRNA complexity in the mammalian brain

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Although there are only 22,000 human genes, most express multiple mRNA isoforms through alternative splicing and selection of alternative 5′ and 3′ ends. A new study identifies the role of alternative splicing in maintaining neuronal excitability in the adult mouse brain.

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Figure 1: A hypothetical model for pre-mRNA targets of the three Rbfox paralogs expressed in mouse brain.

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  1. Thomas A. Cooper is at the Baylor College of Medicine, Houston, Texas, USA.,

    Thomas A Cooper

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  1. Thomas A Cooper
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Correspondence to Thomas A Cooper.

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Cooper, T. Regulating mRNA complexity in the mammalian brain. Nat Genet 43, 618–619 (2011). https://doi.org/10.1038/ng.867

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