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Genetic insights into mammalian heart regeneration

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Genetic and functional analyses of 120 mouse strains have identified a heart regeneration candidate gene that modulates the contractile sarcomeric apparatus. This gene, Tnni3k, controls the frequency of the mononuclear, diploid cardiomyocyte population, which affects cardiomyocyte proliferative potential after injury.

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Figure 1: Genetic influence on heart regeneration.

Debbie Maizels/Springer Nature

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Authors and Affiliations

  1. the Department of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA

    Ana Vujic, Vinícius Bassaneze & Richard T Lee

Authors
  1. Ana Vujic
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  2. Vinícius Bassaneze
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  3. Richard T Lee
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Correspondence to Richard T Lee.

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The authors declare no competing financial interests.

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Vujic, A., Bassaneze, V. & Lee, R. Genetic insights into mammalian heart regeneration. Nat Genet 49, 1292–1293 (2017). https://doi.org/10.1038/ng.3942

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