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Starting embryonic transcription for the first time

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Three studies highlight DUX proteins as key transcription factors regulating embryonic genome activation in early mammalian development.

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Figure 1: Function of DUX proteins in mouse and human cells.

References

  1. Liang, H.L. et al. Nature 456, 400–403 (2008).

    Article  CAS  Google Scholar 

  2. Hendrickson, P.G. et al. Nat. Genet. 49, 925–934 (2017).

    Article  CAS  Google Scholar 

  3. De Iaco, A. et al. Nat. Genet. 49, 941–945 (2017).

    Article  CAS  Google Scholar 

  4. Whiddon, J.L., Langford, A.T., Wong, C.-J., Zhong, J.W. & Tapscott, S.J. Nat. Genet. 49, 935–940 (2017).

    Article  CAS  Google Scholar 

  5. Geng, L.N. et al. Dev. Cell 22, 38–51 (2012).

    Article  CAS  Google Scholar 

  6. Young, J.M. et al. PLoS Genet. 9, e1003947 (2013).

    Article  Google Scholar 

  7. Macfarlan, T.S. et al. Nature 487, 57–63 (2012).

    Article  CAS  Google Scholar 

  8. Ishiuchi, T. et al. Nat. Struct. Mol. Biol. 22, 662–671 (2015).

    Article  CAS  Google Scholar 

  9. Eckersley-Maslin, A.A. et al. Cell Rep. 17, 179–192 (2016).

    Article  CAS  Google Scholar 

  10. Peaston, A.E. et al. Dev. Cell 7, 597–606 (2004).

    Article  CAS  Google Scholar 

  11. Boškovic´, A. et al. Genes Dev. 28, 1042–1047 (2014).

    Article  Google Scholar 

  12. Wu, J. et al. Nature 534, 652–657 (2016).

    Article  CAS  Google Scholar 

  13. Choi, S.H. et al. Nucleic Acids Res. 44, 5161–5173 (2016).

    Article  CAS  Google Scholar 

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Correspondence to Maria-Elena Torres-Padilla.

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Iturbide, A., Torres-Padilla, ME. Starting embryonic transcription for the first time. Nat Genet 49, 820–821 (2017). https://doi.org/10.1038/ng.3880

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