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Uncertainties in tumor allele frequencies limit power to infer evolutionary pressures

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Figure 1: Comparison of evolutionary models for TCGA and simulated data.

References

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Acknowledgements

We would like to thank H.S. Kim for helpful discussions and J. Cha for graphics design. J.H.C. was supported by the National Cancer Institute of the NIH under award R21CA191848 and supplement R21CA191848-01A1S1. Research was also partially supported by the National Cancer Institute under award P30CA034196.

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Authors and Affiliations

  1. The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA

    Javad Noorbakhsh & Jeffrey H Chuang

  2. Department of Genetics and Genome Sciences, University of Connecticut Health Center, Farmington, Connecticut, USA

    Jeffrey H Chuang

Authors
  1. Javad Noorbakhsh
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  2. Jeffrey H Chuang
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Correspondence to Jeffrey H Chuang.

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The authors declare no competing financial interests.

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ipython notebook with code used for computations. (TXT 174 kb)

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Noorbakhsh, J., Chuang, J. Uncertainties in tumor allele frequencies limit power to infer evolutionary pressures. Nat Genet 49, 1288–1289 (2017). https://doi.org/10.1038/ng.3876

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