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Innate and adaptive immunity shape circulating HCV strains

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An unbiased genome-to-genome analysis in chronic hepatitis C virus (HCV) infection confirms the innate and adaptive arms of the immune system as drivers of viral evolution. Viral adaptation has a critical role in the interaction between host and pathogen and has important clinical implications for infection outcome.

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Figure 1: The host antiviral immune response is a major driver of HCV evolution.

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Authors and Affiliations

  1. the Division of Infectious Disease, Department of Medicine, Silvana Gaudieri is in the School of Human Sciences, University of Western Australia, Perth, Western Australia, Australia, Vanderbilt University Medical Center, Nashville, Tennessee, USA, and the Institute for Immunology and Infectious Diseases, Murdoch University, Perth, Western Australia, Australia.,

    Silvana Gaudieri

  2. Michaela Lucas is at the Institute for Immunology and Infectious Diseases, Murdoch University, Perth, Western Australia, Australia, the School of Medicine and Pharmacology, Harry Perkins Institute, University of Western Australia, Perth, Western Australia, Australia, and the School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Western Australia, Australia.,

    Michaela Lucas

Authors
  1. Silvana Gaudieri
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  2. Michaela Lucas
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Correspondence to Silvana Gaudieri.

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The authors declare no competing financial interests.

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Gaudieri, S., Lucas, M. Innate and adaptive immunity shape circulating HCV strains. Nat Genet 49, 657–658 (2017). https://doi.org/10.1038/ng.3856

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