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A SMARCD2-containing mSWI/SNF complex is required for granulopoiesis

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Mammalian SWI/SNF complexes have critical roles in development and differentiation, and are implicated in the pathogenesis of several diseases; however, the mechanisms underpinning disease manifestation and the specificity of the subunits mutated are incompletely understood. Newly identified loss-of-function mutations in the SMARCD2 gene (part of the SMARCD1, SMARCD2 and SMARCD3 paralog family) reveal an evolutionarily conserved role specifically for the SMARCD2 subunit in granulopoiesis, and further investigation implicates the CEBPɛ transcription factor as a key effector of this specific function.

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Figure 1: SMARCD2-containing mSWI/SNF complexes in granulopoiesis.

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Authors and Affiliations

  1. Brittany C. Michel and Cigall Kadoch are in the Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA, and at the Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.,

    Brittany C Michel & Cigall Kadoch

  2. Brittany C. Michel is also in the Biological and Biomedical Sciences Graduate Program, Harvard Medical School, Boston, Massachusetts, USA.,

    Brittany C Michel

Authors
  1. Brittany C Michel
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  2. Cigall Kadoch
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Correspondence to Cigall Kadoch.

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Competing interests

C.K. is a scientific founder of Foghorn Therapeutics, Inc. (Cambridge, MA)

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Michel, B., Kadoch, C. A SMARCD2-containing mSWI/SNF complex is required for granulopoiesis. Nat Genet 49, 655–657 (2017). https://doi.org/10.1038/ng.3853

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