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Finding host targets for HIV therapy

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A CRISPR screen conducted in a CD4+ T cell leukemia line has identified host factors required for HIV infection but dispensable for cellular survival. The results highlight sulfation on the HIV co-receptor CCR5 and cellular aggregation as potential targets for therapeutic intervention.

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Figure 1: Sulfation of CCR5 and cell–cell adhesion are host processes crucial for HIV entry and spread.

Marina Corral Spence/Springer Nature

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Authors and Affiliations

  1. Amita Gupta and Michael C. Bassik are in the Departments of Genetics and Chemistry, C. Kimberly Tsui, Engineering and Medicine for Human Health (ChEM-H), Stanford University, Stanford, California, USA.,

    C Kimberly Tsui, Amita Gupta & Michael C Bassik

Authors
  1. C Kimberly Tsui
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  2. Amita Gupta
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  3. Michael C Bassik
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Correspondence to Michael C Bassik.

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The authors declare no competing financial interests.

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Tsui, C., Gupta, A. & Bassik, M. Finding host targets for HIV therapy. Nat Genet 49, 175–176 (2017). https://doi.org/10.1038/ng.3777

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