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p53 partners with RNA in the DNA damage response

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Stabilization of p53 protein is a key step in the cellular response to DNA damage. A new study describes a long noncoding RNA, DINO, transcribed from the CDKN1A promoter region that induces stabilization of p53 protein and promotes efficient activation of p53 target genes in response to DNA damage.

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Figure 1: Model of DINO function.

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Authors and Affiliations

  1. Department of Gene Therapy and Regulation of Gene Expression, Maite Huarte is at the Center for Applied Medical Research (CIMA), University of Navarra and the Institute of Health Research of Navarra (IdiSNA), Pamplona, Spain.,

    Maite Huarte

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  1. Maite Huarte
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Correspondence to Maite Huarte.

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Huarte, M. p53 partners with RNA in the DNA damage response. Nat Genet 48, 1298–1299 (2016). https://doi.org/10.1038/ng.3702

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