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Nucleosome mapping in plasma DNA predicts cancer gene expression

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A new study demonstrates that genomic sequencing coverage of plasma DNA fragments around transcription start sites reflects the expression levels of genes in corresponding tumors. This approach may enable noninvasive monitoring of treatment-induced changes in gene expression for patients with cancer.

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Figure 1: Sequencing coverage at transcription start sites in plasma DNA correlates with gene expression.

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Authors and Affiliations

  1. Muhammed Murtaza is at the Center for Noninvasive Diagnostics, Translational Genomics Research Institute, Phoenix, Arizona, USA, and the Mayo Clinic Center for Individualized Medicine, Scottsdale, Arizona, USA.,

    Muhammed Murtaza

  2. Department of Oncology, Carlos Caldas is at the Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK, and the Cambridge Cancer Centre, University of Cambridge, Cambridge, UK.,

    Carlos Caldas

Authors
  1. Muhammed Murtaza
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  2. Carlos Caldas
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Correspondence to Muhammed Murtaza or Carlos Caldas.

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Competing interests

M.M. and C.C. are inventors or contributors on patents describing methods for circulating tumor DNA analysis.

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Murtaza, M., Caldas, C. Nucleosome mapping in plasma DNA predicts cancer gene expression. Nat Genet 48, 1105–1106 (2016). https://doi.org/10.1038/ng.3686

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