Skip to main content
SpringerLink
Log in

Poised for development

  • News & Views
  • Published:

From Nature Genetics

View current issue Submit your manuscript

A new study tracks the distribution of bivalent H3K4me3/H3K27me3 chromatin in male germ cells of six vertebrate species. The results have big implications for understanding the mechanisms that specify animal development.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Core poised genes, marked by H3K4me3 and H3K27me3 (indicated here by mock ChIP-seq reads), arose before the amniote common ancestor in many cases and often correspond to genes responsible for ancient regulation of somatic development.

Marina Coral Spence/Nature Publishing Group

References

  1. Bernstein, B.E. et al. Cell 125, 315–326 (2006).

    Article  CAS  PubMed  Google Scholar 

  2. Noordermeer, D. et al. eLife 3, e02557 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Lesch, B.J., Dokshin, G.A., Young, R.A., McCarrey, J.R. & Page, D.C. Proc. Natl. Acad. Sci. USA 110, 16061–16066 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Lesch, B.J., Silber, S.J., McCarrey, J.R. & Page, D.C. Nat. Genet. 48, 888–894 (2016).

    Article  CAS  PubMed  Google Scholar 

  5. Bürglin, T.R. & Affolter, M. Chromosoma 125, 497–521 (2016).

    Article  PubMed  Google Scholar 

  6. El-Sharnouby, S., Redhouse, J. & White, R.A. PLoS Genet. 9, e1003842 (2013).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Cao, R. et al. Science 298, 1039–1043 (2002).

    CAS  PubMed  Google Scholar 

  8. Hou, Z.C. et al. Genome Biol. Evol. 4, 713–725 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Barrow, K.M., Ward, C.M., Rutter, J., Ali, S. & Stern, P.L. Dev. Dyn. 233, 1535–1545 (2005).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Lauren A. Choate and Charles G. Danko are at the Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.,

    Lauren A Choate & Charles G Danko

  2. Charles G. Danko is also in the Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.,

    Charles G Danko

Authors
  1. Lauren A Choate
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Charles G Danko
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Charles G Danko.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Choate, L., Danko, C. Poised for development. Nat Genet 48, 822–823 (2016). https://doi.org/10.1038/ng.3628

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng.3628

  • Springer Nature America, Inc.

Search

Navigation