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Tet proteins enhance the developmental hourglass

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A new study compares DNA methylation profiles in developing zebrafish, Xenopus tropicalis and mice and suggests roles for Tet proteins in demethylating conserved gene enhancers during the phylotypic period of early development. These findings provide an epigenetic underpinning for the 'hourglass' model.

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Figure 1: Depiction of the hourglass model of early development and its molecular underpinning.

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Authors and Affiliations

  1. Peter G. Hendrickson and Bradley R. Cairns are in the Howard Hughes Medical Institute and the Department of Oncological Sciences, University of Utah School of Medicine, Huntsman Cancer Institute, Salt Lake City, Utah, USA.,

    Peter G Hendrickson & Bradley R Cairns

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  1. Peter G Hendrickson
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  2. Bradley R Cairns
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Correspondence to Bradley R Cairns.

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The authors declare no competing financial interests.

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Hendrickson, P., Cairns, B. Tet proteins enhance the developmental hourglass. Nat Genet 48, 345–347 (2016). https://doi.org/10.1038/ng.3533

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