Skip to main content
SpringerLink
Log in

Small island, big genetic discoveries

  • News & Views
  • Published:

From Nature Genetics

View current issue Submit your manuscript

Three new studies have identified new genes and sequence variants implicated in blood lipids, inflammatory markers, hemoglobin levels and adult height variation in Sardinia. These reports highlight the usefulness of large-scale genotype imputation based on whole-genome sequencing, particularly in isolated populations, in studying the genetics of complex human phenotypes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Sardinia was initially populated by people who originated mostly from the Iberian and Italian peninsulas.

Katie Vicari/Nature Publishing Group

References

  1. Peltonen, L., Palotie, A. & Lange, K. Nat. Rev. Genet. 1, 182–190 (2000).

    Article  CAS  Google Scholar 

  2. Sidore, C. et al. Nat. Genet. 47, 1272–1281 (2015).

    Article  CAS  Google Scholar 

  3. Danjou, F. et al. Nat. Genet. 47, 1264–1271 (2015).

    Article  CAS  Google Scholar 

  4. Zoledziewska, M. et al. Nat. Genet. 47, 1352–1356 (2015).

    Article  CAS  Google Scholar 

  5. Kong, A. et al. Nat. Genet. 40, 1068–1075 (2008).

    Article  CAS  Google Scholar 

  6. 1000 Genomes Project Consortium. Nature 491, 56–65 (2012).

  7. Do, R. et al. Nature 518, 102–106 (2015).

    Article  CAS  Google Scholar 

  8. Sankaran, V.G., Lettre, G., Orkin, S.H. & Hirschhorn, J.N. Ann. NY Acad. Sci. 1214, 47–56 (2010).

    Article  CAS  Google Scholar 

  9. Wood, A.R. et al. Nat. Genet. 46, 1173–1186 (2014).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Guillaume Lettre is at the Montreal Heart Institute, Montreal, Quebec, Canada, and the Faculté de Médecine, Université de Montréal, Montreal, Quebec, Canada.,

    Guillaume Lettre

  2. Joel N. Hirschhorn is at the Division of Endocrinology and Center for Basic and Translational Obesity Research, and the Department of Genetics, Boston Children's Hospital, Boston, Massachusetts, USA, the Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA, Harvard Medical School, Boston, Massachusetts, USA.,

    Joel N Hirschhorn

Authors
  1. Guillaume Lettre
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Joel N Hirschhorn
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Guillaume Lettre or Joel N Hirschhorn.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lettre, G., Hirschhorn, J. Small island, big genetic discoveries. Nat Genet 47, 1224–1225 (2015). https://doi.org/10.1038/ng.3426

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng.3426

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation