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Building a staircase to precision medicine for biliary tract cancer

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A new study has conducted a comprehensive exome and transcriptome analysis of a large number of intrahepatic, perihilar and distal cholangiocarcinomas and gallbladder cancers in Japanese patients. This study identifies many new alterations, confirms genetic differences in these distinct subtypes of biliary tract cancer and demonstrates that approximately 40% of described genetic aberrations are potentially targetable.

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Figure 1

Marina Corral Spence/Nature Publishing Group

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Authors and Affiliations

  1. Nataliya Razumilava is in the Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA.,

    Nataliya Razumilava

  2. Gregory J. Gores is in the Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.,

    Gregory J Gores

Authors
  1. Nataliya Razumilava
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  2. Gregory J Gores
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Corresponding author

Correspondence to Gregory J Gores.

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The authors declare no competing financial interests.

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Razumilava, N., Gores, G. Building a staircase to precision medicine for biliary tract cancer. Nat Genet 47, 967–968 (2015). https://doi.org/10.1038/ng.3386

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