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Pediatric cancer genomics, a play rather than a portrait

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Relapsed neuroblastoma is common, frequently lethal and poorly studied and poses a major treatment challenge. Two new studies shed light on the genomic landscape of recurrent neuroblastoma and demonstrate profound differences between the disease at diagnosis and relapse.

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Figure 1: Recurrent neuroblastoma arises from a treatment-resistant clone of the primary tumor.

Marina Corral Spence/Nature Publishing Group

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Authors and Affiliations

  1. Vijay Ramaswamy is in the Division of Haematology/Oncology, Hospital for Sick Children, Toronto, Ontario, Canada.,

    Vijay Ramaswamy

  2. Michael D. Taylor is in the Division of Neurosurgery, Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.,

    Michael D Taylor

Authors
  1. Vijay Ramaswamy
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  2. Michael D Taylor
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Correspondence to Michael D Taylor.

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The authors declare no competing financial interests.

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Ramaswamy, V., Taylor, M. Pediatric cancer genomics, a play rather than a portrait. Nat Genet 47, 851–852 (2015). https://doi.org/10.1038/ng.3366

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