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Transposon mutagenesis disentangles osteosarcoma genetic drivers

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The genetic drivers of osteosarcoma have been difficult to identify because of the genomic complexity consistently encountered in cancer cells at diagnosis. A new study uses Sleeping Beauty transposon mutagenesis to drive osteosarcomagenesis in the mouse and identify likely drivers of the disease in humans.

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Figure 1: Transposon-mediated mutagenesis.

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Authors and Affiliations

  1. Kevin B. Jones is at the Department of Orthopedics and the Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA.,

    Kevin B Jones

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  1. Kevin B Jones
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Correspondence to Kevin B Jones.

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The author declares no competing financial interests.

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Jones, K. Transposon mutagenesis disentangles osteosarcoma genetic drivers. Nat Genet 47, 564–565 (2015). https://doi.org/10.1038/ng.3317

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