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Hypertension linked to PDE3A activation

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A new study identifies PDE3A mutations as the cause of brachydactyly type E with hypertension. These mutations alter PDE3A activity by uncovering cryptic sites for phosphorylation by PKA and PKC, leading to enzyme hyperactivation that abnormally lowers cAMP levels.

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Figure 1: HTNB-associated mutations alter PDE3A activity.

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Authors and Affiliations

  1. Miles Houslay is at the Institute of Pharmaceutical Science, King's College London, London, UK, and Mironid, Ltd., BioCity Scotland, Newhouse, UK.,

    Miles Houslay

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  1. Miles Houslay
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Correspondence to Miles Houslay.

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Houslay, M. Hypertension linked to PDE3A activation. Nat Genet 47, 562–563 (2015). https://doi.org/10.1038/ng.3316

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