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A shared architecture for promoters and enhancers

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A new study detects unstable nascent RNAs and uncovers thousands of transcription initiation sites in promoters and enhancers. Detailed analysis shows that these initiation sites have a similar architecture and that they are differentiated by post-transcriptional regulation rather than transcription initiation.

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Figure 1: The architecture of initiation sites and transcript stability in promoters and enhancers.

Debbie Maizels/Nature Publishing Group

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Authors and Affiliations

  1. Shira Weingarten-Gabbay and Eran Segal are in the Department of Computer Science and Applied Mathematics and the Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.,

    Shira Weingarten-Gabbay & Eran Segal

Authors
  1. Shira Weingarten-Gabbay
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  2. Eran Segal
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Correspondence to Eran Segal.

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The authors declare no competing financial interests.

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Weingarten-Gabbay, S., Segal, E. A shared architecture for promoters and enhancers. Nat Genet 46, 1253–1254 (2014). https://doi.org/10.1038/ng.3152

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