Febrile seizures can arise in response to fevers induced by viral infection or as an adverse reaction to live-virus vaccines such as measles, mumps and rubella (MMR) vaccination. A new study has now identified common genetic variants influencing susceptibility to febrile seizures, including two loci specifically associated with MMR-related events.
References
Cross, J.H. Epilepsia 53 (suppl. 4), 3–8 (2012).
Feenstra, B. et al. Nat. Genet. 46, 1274–1282 (2014).
Sadleir, L.G. & Scheffer, I.E. Br. Med. J. 334, 307–311 (2007).
Oliva, M., Berkovic, S.F. & Petrou, S. Epilepsia 53, 1849–1859 (2012).
Schutte, R.J. et al. J. Neurophysiol. 112, 903–912 (2014).
Thomas, E.A. et al. Ann. Neurol. 66, 219–226 (2009).
Yuen, A.W. & Sander, J.W. Epilepsy Res. 100, 152–156 (2012).
International League Against Epilepsy Consortium on Complex Epilepsies. Lancet Neurol. 13, 893–903 (2014).
Kasperaviciute, D. et al. Brain 136, 3140–3150 (2013).
Tang, L. et al. Gene 533, 26–31 (2014).
Hesdorffer, D.C. et al. Epilepsia 53, 1471–1480 (2012).
Kramer, U. et al. Epilepsia 52, 1956–1965 (2011).
Varadkar, S. et al. Lancet Neurol. 13, 195–205 (2014).
Scott, R.C. Curr. Opin. Pediatr. doi:10.1097/MOP.0000000000000153 (8 October 2014).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Sisodiya, S. Feverish prospects for seizure genetics. Nat Genet 46, 1255–1256 (2014). https://doi.org/10.1038/ng.3150
Published:
Issue Date:
DOI: https://doi.org/10.1038/ng.3150
- Springer Nature America, Inc.