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RNA switch at enhancers

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Polycomb/Trithorax response elements (PRE/TREs) are genetic elements that can stably silence or activate genes. A new study describes how long noncoding RNAs (lncRNAs) transcribed from opposite strands of the Drosophila melanogaster vestigial PRE/TRE throw the switch between these two opposing epigenetic states.

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Figure 1: Model of GEAR box function at the vg locus.

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Authors and Affiliations

  1. Jeffrey J. Quinn is in the Department of Bioengineering at Stanford University, Stanford, California, USA.,

    Jeffrey J Quinn

  2. Howard Y. Chang is in the Program in Epithelial Biology and the Howard Hughes Medical Institute at Stanford University, Stanford, California, USA.,

    Howard Y Chang

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  1. Jeffrey J Quinn
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  2. Howard Y Chang
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Correspondence to Howard Y Chang.

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Quinn, J., Chang, H. RNA switch at enhancers. Nat Genet 46, 929–931 (2014). https://doi.org/10.1038/ng.3074

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