Sex chromosomes in mammals, birds, reptiles and fish represent many independent evolutionary events, but there is spectacular convergence and stunning parallels. A new study details the early stages of ZW differentiation and sex determination in a flatfish and the establishment of dosage compensation and sex reversal by epigenetic mechanisms including DNA methylation.
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Graves, J. The epigenetic sole of sex and dosage compensation. Nat Genet 46, 215–217 (2014). https://doi.org/10.1038/ng.2903
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DOI: https://doi.org/10.1038/ng.2903
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