A new study shows that HOXB13 is preferentially recruited to the risk allele of a prostate cancer–associated SNP, enhancing the expression of RFX6, a driver of prostate cancer cell migration and predictor of disease progression. The work illustrates how a single risk locus contributes both to prostate cancer incidence and, through functional follow-up, to disease progression.
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Mills, I. HOXB13, RFX6 and prostate cancer risk. Nat Genet 46, 94–95 (2014). https://doi.org/10.1038/ng.2881
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DOI: https://doi.org/10.1038/ng.2881
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