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Genetic signature of bacterial pathogen adaptation during chronic pulmonary infections

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To establish and maintain chronic infections, many pathogens adapt in response to selective pressures within the host, leaving unique genetic signatures. A new study uses whole-genome and population sequencing approaches to identify evidence of adaptive evolution in Burkholderia dolosa genomes isolated from chronic infections in patients with cystic fibrosis.

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Figure 1: Population heterogeneity of pathogens within cystic fibrosis airways.

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Authors and Affiliations

  1. Department of Medicine, Steve P. Bernier, Matthew L. Workentine and Michael G. Surette are at the Farncombe Family Digestive Health Research Institute, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.,

    Steve P Bernier, Matthew L Workentine & Michael G Surette

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  1. Steve P Bernier
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  2. Matthew L Workentine
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  3. Michael G Surette
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Correspondence to Michael G Surette.

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Bernier, S., Workentine, M. & Surette, M. Genetic signature of bacterial pathogen adaptation during chronic pulmonary infections. Nat Genet 46, 5–6 (2014). https://doi.org/10.1038/ng.2859

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