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Epigenetics, vitamin supplements and cellular reprogramming

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The simple addition of vitamin C to cell culture medium can induce extensive remodeling of the cellular epigenome and facilitates reprogramming of somatic cells to pluripotency. A new study shows that the activity of the enzyme TET1 can inhibit or enhance reprogramming efficiency, dependent on the presence or absence of vitamin C.

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Figure 1: The effects of TET1 deficiency are dependent on the presence of vitamin C in the medium.

Katie Vicari

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Authors and Affiliations

  1. Martin F. Pera is at the Department of Anatomy and Neuroscience, University of Melbourne, the Walter and Eliza Hall Institute of Medical Research, and the Florey Neuroscience and Mental Health Institute, Melbourne, Victoria, Australia.,

    Martin F Pera

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  1. Martin F Pera
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Correspondence to Martin F Pera.

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Pera, M. Epigenetics, vitamin supplements and cellular reprogramming. Nat Genet 45, 1412–1413 (2013). https://doi.org/10.1038/ng.2834

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