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No pain, more gain

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A new study shows that a specific mutation in SCN11A, which encodes the Nav1.9 voltage-gated sodium channel, underlies a human disorder characterized by insensitivity to pain. This finding provides fresh insights into human pain perception and suggests a new avenue for the development of analgesic drugs.

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Authors and Affiliations

  1. Molecular Nociception Group at the Wolfson Institute for Biomedical Research, University College London, London, UK

    James J Cox & John N Wood

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  1. James J Cox
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  2. John N Wood
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Correspondence to John N Wood.

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The authors declare no competing financial interests.

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Cox, J., Wood, J. No pain, more gain. Nat Genet 45, 1271–1272 (2013). https://doi.org/10.1038/ng.2810

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