Skip to main content

Advertisement

SpringerLink
Log in

Mining the epigenetic landscape in ALL

  • News & Views
  • Published:

From Nature Genetics

View current issue Submit your manuscript

The significance of epigenomic aberrations in cancer development has been underscored by the discovery of mutations in key chromatin modifiers, most notably in hematological malignancies. A new study of pediatric acute lymphoblastic leukemia (ALL) demonstrates the usefulness of mapping global epigenetic signatures and applying these data in a framework to identify and characterize underlying somatic genetic alterations in human cancers.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Schematic of the chromatin signature that was studied by Stegmeier and colleagues.

Katie Vicari

References

  1. Knutson, S.K. et al. Nat. Chem. Biol. 8, 890–896 (2012).

    Article  CAS  PubMed  Google Scholar 

  2. McCabe, M.T. et al. Nature 492, 108–112 (2012).

    Article  CAS  PubMed  Google Scholar 

  3. Bernt, K.M. et al. Cancer Cell 20, 66–78 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Jaffe, J.D. et al. Nat. Genet. 45, 1386–1391 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Barretina, J. et al. Nature 483, 603–607 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Yap, D.B. et al. Blood 117, 2451–2459 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Ernst, T. et al. Nat. Genet. 42, 722–726 (2010).

    Article  CAS  PubMed  Google Scholar 

  8. Yuan, W. et al. J. Biol. Chem. 286, 7983–7989 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Martinez-Garcia, E. et al. Blood 117, 211–220 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Kuo, A.J. et al. Mol. Cell 44, 609–620 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Shen, X. et al. Mol. Cell 32, 491–502 (2008).

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Loh, M.L. & Mullighan, C.G. Clin. Cancer Res. 18, 2754–2767 (2012).

    Article  CAS  PubMed  Google Scholar 

  13. Shurtleff, S.A. et al. Leukemia 9, 1985–1989 (1995).

    CAS  PubMed  Google Scholar 

  14. Jaju, R.J. et al. Blood 98, 1264–1267 (2001).

    Article  CAS  PubMed  Google Scholar 

  15. Rosati, R. et al. Blood 99, 3857–3860 (2002).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    Lindsay M LaFave & Ross L Levine

  2. Gerstner Sloan-Kettering Graduate School, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    Lindsay M LaFave

  3. Department of Medicine, Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    Ross L Levine

Authors
  1. Lindsay M LaFave
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ross L Levine
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ross L Levine.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

LaFave, L., Levine, R. Mining the epigenetic landscape in ALL. Nat Genet 45, 1269–1270 (2013). https://doi.org/10.1038/ng.2808

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng.2808

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation