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Linking the SWI/SNF complex to prostate cancer

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Genes encoding subunits of the SWI/SNF chromatin-remodeling complex constitute, collectively, one of the most frequently mutated targets in cancer. Although mutations in SWI/SNF genes are uncommon in prostate cancer, a new study shows that SChLAP1, a long noncoding RNA frequently expressed in aggressive prostate tumors, drives cancer by directly disrupting SNF5, a core subunit of the SWI/SNF complex.

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Figure 1: Aberrantly high expression of SChLAP1 in aggressive prostate cancers inhibits SWI/SNF-mediated epigenetic regulation.

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Authors and Affiliations

  1. Department of Pediatric Oncology, the Division of Hematology-Oncology, Boston Children's Hospital and the Department of Biological Chemistry and Molecular Pharmacology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA

    Ryan S Lee & Charles W M Roberts

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  1. Ryan S Lee
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  2. Charles W M Roberts
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Correspondence to Charles W M Roberts.

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The authors declare no competing financial interests.

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Lee, R., Roberts, C. Linking the SWI/SNF complex to prostate cancer. Nat Genet 45, 1268–1269 (2013). https://doi.org/10.1038/ng.2805

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