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MAPping the genomic landscape of low-grade pediatric gliomas

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Two recent large-scale sequencing studies have identified multiple genetic aberrations in pediatric low-grade gliomas. These findings offer substantial insights that may spur the development of new diagnostics and treatments for these cancers.

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Figure 1: The majority of genetic alterations in pediatric LGGs activate the MAPK-ERK pathway.

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Correspondence to Timothy A Chan.

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Turcan, S., Chan, T. MAPping the genomic landscape of low-grade pediatric gliomas. Nat Genet 45, 847–849 (2013). https://doi.org/10.1038/ng.2706

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